The psychological state of being irritated or annoyed.
Something about this definition bothers me. I think it is the word "psychological." "Botheration" seems like a contrived word, one which might be used to demonstrate a point or to inject attitude. It would not seem to capture an extraordinary level of nervousness or a high state of being bothered. Rather, it seems to capture a state in which one very much needs or wants to communicate the fact that they are bothered by something. That is how I look at this bother-bodied word.
